The research group “Modelling and Imaging Pancreatic Cancer using
Conditional Mouse Models” (Head: Dr. Jens Siveke) in the II. Medical
Department at the Klinikum rechts der Isar (Gastroenterology) of the
Technical University of Munich invites applications for
a Postdoctoral Position (f/m) and a PhD Position (f/m)
Area of research: Our group is studying the biology of pancreatic diseases and in particular pancreatic cancer using conditional mouse models. For this project (“Evaluation of therapeutic strategies and monitoring through multi modal imaging in genetically engineered mice with endogenous pancreatic cancer“) within the newly formed SFB 824 “Imaging for the Selection,
Monitoring and Individualisation of Cancer Therapy” we are particularly interested in studying multimodal imaging such as MRT and PET as well as molecular imaging during development and therapy of pancreatic cancer in complex mouse models. Our interdisciplinary approach ranges from mouse genetics and molecular medicine to applying therapeutic studies in a preclinical setting using multiple imaging modalities.
Key References:
Siveke JT, Einwächter H, Lubeseder-Martellato C, Sipos B, Klöppel G,
Schmid RM. Concomitant pancreatic activation of KrasG12D and Tgfa
results in cystic papillary neoplasms reminiscent of human IPMN. Cancer
Cell. 2007;12:266-279.
Siveke JT, Schmid RM. Chromosomal instability in mouse metastatic pancreatic
cancer--it's Kras and Tp53 after all. Cancer Cell. 2005;7:405-7.
Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke
F, Schmid RM. Notch signaling is required for exocrine regeneration after
acute pancreatitis. Gastroenterology. 2008;134:544-55.
Prerequisite: Applicants must have a Ph.D. and/or M.D. postdoctoral training. A strong background in mouse genetics working techniques, molecular biology and molecular imaging will be of advantage. The ideal applicant is a very motivated and goal-oriented scientist.
Payment is according to tariff (TV-L).
We give priority to applicants with a disability and essentially equal qualifications.
Starting date: The position is available as from August 2009 but later starting dates are possible.
Duration: Initially for 4 years with an option for extension.
Apply to: Please send your application (including CV, list of publications, and 2-3 references)
preferentially by Email to:
Dr. Jens Siveke
(jens.siveke@lrz.tum.de),
II. Medizinische Klinik (Gastroenterologie),
Technische Universität München,
Ismaninger Straße 22, 81675 München.
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