The Division of Signal Transduction and Growth Control is searching for a Postdoctoral

The German Cancer Research Center is the largest biomedical
research institution in Germany. With more than 2100 employees,
we operate an extensive scientific program in the field of cancer

The Division of Signal Transduction and Growth Control is searching for a
Postdoctoral Fellow
(Ref-No. 34/2009)

The repair of cutaneous wounds is a complex, highly orchestrated
multi-cellular process ensuring the rapid restoration of the
integrity of an organism. To study signal transduction pathways
and genetic programs in wound healing we have employed 2D
and 3D organotypic co-culture systems containing cells from
genetically modified mice to identify an essential role of
transcription factor AP-1 (Fos/Jun), as well as AP-1-regulated
cytokines in cell-cell communication during wound healing
(Szabowski et al., 2000 Cell, 103, 745; Florin et al., 2005, J Cell
Sci 118,1981). Recently, a systems biology approach was
employed to unravel the network topology and simulate the
spatio-temporal regulatory network of gene expression controlling
epidermal cell migration during wound healing (Busch et al.,
2008, Mol Syst Biol 4, 199). To follow up on these findings we will
study cell-cell communication and gene programs implicated in
cell proliferation, migration and differentiation in order to define
genetic networks underlying wound healing pathology. The
project is embedded within the BMBF Initiative “Systems Biology
in Medicine, MedSys” focussing on the topic “Chronic Wounds”.
Thus, the successful candidate is also expected to coordinate/
participate in collaborative research activities with other groups
of the consortium.

Your profile:
– MD or PhD in Biology/Biochemistry
– excellent background/interest in molecular and cellular biology
of the skin
– basic knowledge of/ interest in bioinformatics and systems

The position is available immediately and limited until January 31,

For further information please contact Prof. Dr. Peter Angel,
phone 06221 42-4570.
The German Cancer Research Center is committed to increase
the representation of women in science and encourages
applications from qualified female scientists. Persons with
disabilities will be given preference among equally qualified

Please send your application to:
Deutsches Krebsforschungszentrum
Personal- und Sozialwesen
Im Neuenheimer Feld 280
69120 Heidelberg

Or apply online: www.dkfz.de