For a European Union funded project on cellular and molecular mechanisms of arrhythmia, we seek a highly motivated student for a PhD project, starting immediately, for up to 4 years. Using advanced methods for gene targeting and transgene construction, candidate mutations inducing muscle arrhythmia will be introduced in the animal model Caenorhabditis elegans. Furthermore, optogenetic methods (Channelrhodopsin and Halorhodopsin) will be used. A university degree (Diploma, Master) in molecular biology, biology, biochemistry, or physiology is required. Solid experience in molecular biology methods is a prerequisite, previous experience with C. elegans, as well as with “recombineering” methods, is highly welcome. For more information, see papers and website (find URL below): EMBO J (2005) 24: 2566; Curr. Biol. (2005) 15: 2279; Nature (2007) 446: 633; Nat. Meth. (2008) 5: 895; EMBO J (2009) doi:10.1038/emboj.2009.204. Send CV, description of research experience and interests, certificates, and references to Alexander Gottschalk, no later than August 16th, 2009.

Kontakt:

Alexander Gottschalk (a.gottschalk@em.uni-frankfurt.de)

Goethe Universität, Institut für Biochemie, Biozentrum N220
Max von Laue Str. 9
D-60438 Frankfurt, Germany

With funding of the DFG Type II collagen-based nanofiber scaffolds for cartilage regeneration a PhD position for a life scientist with strong interest and background in Tissue Engineering strategies is available at the Orthopaedic Center for Musculoskeletal Research (König-Ludwig-Haus) Würzburg. The scientific aim is to investigate cell-matrix interactions of primary cells (MSCs/chondrocytes) on nanofibrous collagen scaffolds in the context of cartilage repair strategies.

Techniques from electrospinning, molecular biology and SEM to bioreactor cell culture will be applied to highlight the regulative key events during chondrogenic differentiation of primary cells in regards to scaffold morphology and biochemistry. Salary is based on TV-L. The position is available from July 1st, 2009 on.

Applications from severely handicapped persons with basically similar qualification will be given priority.

Please send your application by e-mail (single PDF file), including contact details of referees to:

Kontakt:

Dr. Lars Rackwitz (l-rackwitz.klh@mail.uni-wuerzburg.de)

Orthopaedic Center for Musculoskeletal Research
Brettreichstr. 11
97074 Würzburg

Tel.: 0931-8031140