University of Regensburg Department of Cell Biology & Plant Physiology

PhD position

As part of a DFG-project at the Department of Cell Biology and Plant Physiology the University of Regensburg now a doctorate (researcher, E13 / 2) for a period of 3 years to fill.
The aim of the project is the molecular mechanism of a plant Armadillo-repeat protein (ARO1) with the establishment of polarity in the pollen tube and the oocyte [Gebert et al. (2008), enlighten Plant Cell 20: 2798-2814].

The main objectives are the identification and characterization by ARO1-interacting proteins. We seek to implement the project, a / s average motivated / s PhD student with a diploma / MSc in biochemistry, biology or a closely related field. Prerequisites are experience in Knowledge in the field of molecular biology and genetics, protein biochemistry and
plant cell and developmental biology.

We offer the handling of a highly topical and promising topic under excellent working conditions in a new, modern Laboratory and in a scientifically ambitious, international and collegiate Working Group. The project provides a particularly wide range of molecular,
protein biochemistry, cell biology and molecular genetics Methods. As a successful / r candidates in a structured, you will PhD Program in the Department of "Cellular Biochemistry and Biophysics" Regensburg in the International Graduate School of Life Sciences (RIGEL; http://www.biologie.uni-regensburg.de/RIGeL/index.html) conduct.
Your complete application (CV, motivation letter, references) set please contact:

Dr. Stefanie Sprunck
Cell Biology and Plant Physiology, University of Regensburg
Universitätsstr. 31, 93053 Regensburg
E-mail: @ stefanie.sprunck biologie.uni-regensburg.de

Otto-von-Guericke-Universität Magdeburg - Medizinische Fakultät - Department of Experimental Obstetrics and Gynaecology

2 Doktorandenstellen, 2 PhD Positions (50 v. H.; Entgeltgruppe 13 TV-L) 3 years, both prolongables

Topic: “Participation of mast cells in pregnancy success?”

The 2 PhD positions available are granted within the budget from a DFG-funded project
which has as main aim to investigate whether mast cells contribute to pregnancy success,
contrary to the so far known theories but accordingly with the breakthrough new data published for transplantation. We do believe that investigating the participation of MC and MC-related genes in Treg-induced tolerance during pregnancy will contribute to the knowledge of the basic mechanisms regulating immune tolerance during pregnancy, a major biological question with tremendous medical implications in other fields such as transplantation and tumor research.

Qualification/requirements:
We expect theoretical knowledge as well as practical experience in reproductive biology or
immunology and molecular biology, very good English skills, team spirit and the ability of
working independently. The position is open for biologists, biochemists, biotechnologist or
scientists with equal qualification (MSc) willing to perform their PhD in our department.

Solid knowledge in molecular biological and immunological methods is expected. The methods include flow cytometry, embedding in paraffin, cryosection, immunohistochemistry, cell culture among others. Furthermore it is of advantage to have experience with in vivo models (mouse, rat).

Severely disabled persons are with the same qualification considered. Women are especially
requested to make an application.

Applicants should submit their applications (consisting in curriculum vitae, certificates, motivation letter, publications, and two referees) until 31st August 2009 to:
Prof. Dr. Ana Zenclussen
Experimentelle Gynäkologie und Geburtshilfe
Medizinische Fakultät, Otto-von-Guericke-Universität
Haus 103 (Villa)
Gerhart-Hauptmann-Str. 35
39108 Magdeburg, Germany
or per E-Mail to: ana.zenclussen@med.ovgu.de

The research group “Modelling and Imaging Pancreatic Cancer using
Conditional Mouse Models” (Head: Dr. Jens Siveke) in the II. Medical
Department at the Klinikum rechts der Isar (Gastroenterology) of the
Technical University of Munich invites applications for

a Postdoctoral Position (f/m) and a PhD Position (f/m)

Area of research: Our group is studying the biology of pancreatic diseases and in particular pancreatic cancer using conditional mouse models. For this project (“Evaluation of therapeutic strategies and monitoring through multi modal imaging in genetically engineered mice with endogenous pancreatic cancer“) within the newly formed SFB 824 “Imaging for the Selection,
Monitoring and Individualisation of Cancer Therapy” we are particularly interested in studying multimodal imaging such as MRT and PET as well as molecular imaging during development and therapy of pancreatic cancer in complex mouse models. Our interdisciplinary approach ranges from mouse genetics and molecular medicine to applying therapeutic studies in a preclinical setting using multiple imaging modalities.

Key References:

Siveke JT, Einwächter H, Lubeseder-Martellato C, Sipos B, Klöppel G,
Schmid RM. Concomitant pancreatic activation of KrasG12D and Tgfa
results in cystic papillary neoplasms reminiscent of human IPMN. Cancer
Cell. 2007;12:266-279.

Siveke JT, Schmid RM. Chromosomal instability in mouse metastatic pancreatic
cancer--it's Kras and Tp53 after all. Cancer Cell. 2005;7:405-7.

Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke
F, Schmid RM. Notch signaling is required for exocrine regeneration after
acute pancreatitis. Gastroenterology. 2008;134:544-55.

Prerequisite: Applicants must have a Ph.D. and/or M.D. postdoctoral training. A strong background in mouse genetics working techniques, molecular biology and molecular imaging will be of advantage. The ideal applicant is a very motivated and goal-oriented scientist.

Payment is according to tariff (TV-L).

We give priority to applicants with a disability and essentially equal qualifications.

Starting date: The position is available as from August 2009 but later starting dates are possible.

Duration: Initially for 4 years with an option for extension.

Apply to: Please send your application (including CV, list of publications, and 2-3 references)

preferentially by Email to:
Dr. Jens Siveke
(jens.siveke@lrz.tum.de),
II. Medizinische Klinik (Gastroenterologie),
Technische Universität München,
Ismaninger Straße 22, 81675 München.

KLINIKUM RECHTS DER ISAR
DER TECHNISCHEN UNIVERSITÄT MÜNCHEN
- ANSTALT DES ÖFFENTLICHEN RECHTS -

At the Research Center Borstel Leibniz Center for Medicine and
Life Sciences in the Laboratory of Molecular Group Mykobakteriologie
the earliest date PhD position (m / w) be filled.

The candidates should be in the framework of an international research network. Working for a better understanding of resistance development in By mycobacteria. In particular, resistance-mediating Mutations in Mycobacterium tuberculosis complex strains and their effects on bacterial Fit-ness analysis. The planned work will include identifying new
Resistenzvermittelnder genomic variants and their functional validation using isogenic mutant strains. In addition, an influence different genetic variants to bacterial fitness investigated will.

You can expect a young and enthusiastic, especially in emerging Research and an interdisciplinary team working atmosphere. Your profile: You will be given to candidates with a science Diploma or a master's degree sought. Desirable is experience in Dealing with mycobacteria, and molecular biological knowledge. The compensation is based on the TVöD (VKA). There are all in the public Service usual benefits offered. Handicapped applicants will be with otherwise equally qualified preference set.

Further information can be found at www.fz-borstel.de.
Information given PD Dr. Stefan Niemann under sniemann@fz-borstel.de.
Their meaningful written application, please contact the
Human Resources at the Research Center Borstel
Keyword: DokMolMyk
Park Avenue 2, 23845 Borstel
E-mail: personalwesen@fz-borstel.de